Stoldt Group

Group leader

Title	Name	First Name	Position
Prof. M.D. Ph.D.	Scharf	Rüdiger E.	Director

Researchers

Title	Name	First Name	Position
Ph.D.	Stoldt	Volker R.	Group leader
Ph.D.	Gyenes	Marianna	Senior scientist

BioStruct Fellow

Title	Name	First Name	Position
MSc	Huynh	Khon C.	PhD student

 For more information on the principal investigator click here...

Further Team Members

Technicians:	2
PHD/MD students:	6

Contact

Volker R. Stoldt
Dept. of Hemostasis and Transfusion Medicine
Heinrich Heine University Medical Center
Moorenstrasse 5
40225 Düsseldorf
Germany

 +49(0)211 8116916
 +49(0)211 8119230


website:
http://www.uniklinik-duesseldorf.de/transfusionsmedizin

Special Methodical Expertise

• Flow simulation by in vitro flow models and rheometer
• Multiparametric confocal laser scanning microscopy and 3D-imaging
• Multiparametric flow cytometrie and fluorescence imaging

 click here for further information

Main areas of research interest

• Structure and function of integrins
• Mechanotransduction and biomechanic stress
• Protein interactions and cytoskeletal functions/reinforcement

Facilities

The laboratories cover the following gene technology security levels:	S1
The laboratories cover the following biohazard levels:	BSL2

Laboratory Equipment

General equipment available in the laboratories:

• Biochemistry
• Cell culture
• Molecular biology
• Immunology
• Cell Biology
• Imaging

Special equipment, which is not generally available in most laboratories:

• multiparametric confocal laser scanning microscope, multiparametric flow cytometer

Non-standard methods, which are established in the laboratory:

• in vitro flow models combined with diverse fluorescence imaging systems

Important References

• Stoldt VR, Peveling J, Loncar R, Beck A, Aurich V, Scharf RE. (2005) Evaluation of platelet thrombus formation under flow. Blood, 106: 70-71.
• Loncar R, Stoldt V, Hellmig S, Zotz RB, Mihalj M, Scharf RE. (2007) HPA-1 polymorphism of alphaIIbbeta3 modulates platelet adhesion onto immobilized fibrinogen in an in-vitro flow system. Thromb J., 5:2.
• Loncar R, Kalina U, Stoldt V, Thomas V, Scharf RE, Vodovnik A. (2006) Antithrombin significantly influences platelet adhesion onto immobilized fibrinogen in an in-vitro system simulating low flow. Thromb J., 4:19.
• Stoldt VR, Schnorr O, Schulze-Osthoff K, Scharf RE. (2006) Transforming growth factor-beta1 enhances the antifibrinolytic and prothrombotic state of growing endothelial cells in a cell cycle-specific manner. FASEB J., 20:965-6.
• Stoldt VR, Sonneborn A, Leuker CE, Ernst JF. (1997) Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J., 16:1982-91.

Cooperators

• Schulze-Osthoff, Klaus, Prof. Dr., Eberhard Karls University Tuebingen, Germany
• Glassmann, Alexander, Dr., Rheinische Friedrich Wilhelms University Bonn, Germany
• Loncar, Robert, PD Dr., Heinrich Heine University Duesseldorf, Germany