Häussinger Group

Group leader

Title	Name	First Name	Position
Prof. Dr.	Häussinger	Dieter	Professor of Medicine, Director of the Clinic for Gastroenterology, Hepatology and Infectiology

 For more information on the principal investigator click here...

Researchers

Title	Name	First Name	Position
PD Dr.	Reinehr	Roland	Senior Scientist

BioStruct Fellow

Title	Name	First Name	Position
Msc.	Roychoudhury	Arpita	PhD student

 For more information on the biostruct fellow click here...

Further Team Members

Technicians:	6
Master/Diploma students:	1
PHD/MD students:	15

Contact

Clinic for Gastroenterology, Hepatology and Infectiology
University Hospital Düsseldorf
Heinrich Heine University Düsseldorf
Moorenstr. 5
40225 Düsseldorf
Germany

 +49(0)211-81-17569
 +49(0)211-81-18838


website:
 www.uniklinik-duesseldorf.de

Contact 2

Priv.-Doz. Dr. Roland Reinehr
Clinic for Gastroenterology, Hepatology and Infectiology
University Hospital Düsseldorf
Heinrich Heine University Düsseldorf
Moorenstr. 5
40225 Düsseldorf
Germany

+49(0)211-81-18953
+49(0)211-81-18752

Special Methodical Expertise

• FRET and TIRF microscopy
• Live cell imaging/cell observer
• Liver perfusion, liver cell isolation and primary liver cell culture
• Stem cell biology
• Astrocyte biology and hepatic encephalopathy

Main areas of research interest

• Clinical and Experimental Hepatology
• Cell hydration and cell function
• Apoptosis and liver regeneration

Facilities

The laboratories cover the following gene technology security levels:	S1
The laboratories cover the following biohazard levels:	BSL1

Other security laboratories or special facilities:

• Radioactive laboratory
• Animal care facility for rats and mice

Laboratory Equipment

General equipment available in the laboratories:

• Biochemistry
• Immunology
• Histology
• Cell Biology
• Imaging
• Cell culture
• Microbiology
• Molecular biology

Special equipment, which is not generally available in most laboratories:

• FRET microscopy
• TIRF microscopy
• live cell imaging/cell observer

Non-standard methods, which are established in the laboratory:

• Liver perfusion

Important references

• Häberle, J., Görg, B., Rutsch, F., Schmidt, E., Toutain, A., Benoist, J.F., Gelot, A., Suc, A.L., Höhne, W., Schliess, F., Häussinger, D. & Koch, H.G. (2005) Congenital systemic glutamine deficiency with glutamine synthetase mutations. New Engl. J. Med. 353, 38-45
• Warskulat, U., Borsch, E., Reinehr, R., Hell-Stilb, B., Mönnighoff, I., Buchzyk, D., Donner, M., Flögel, U., Kappert, G., Soboll, S., Beer, S., Pfeffer, K., Marschall, U., Gabrielsen, M., Amiry-Moghaddam, M., Dienes, H.P. & Häussinger, D. (2006) Chronic liver disease is triggered by taurine transporter knockout in the mouse. FASEB J. 20, 574-576
• Lang, P.A., Schenck, M., Nicolay, J.P., Becker, J., Kempe, D.S., Lupescu, A., Eisele, K., Klarl, B.A., Rübben, H., Schmidt, K.W., Mann, K., Hildenbrand, S., Huber, S.M., Wieder, T., Erhardt, A., Häussinger, D., Gulbins, S. E. & Lang, F. (2007) Liver cell death and anemia in Wilson´s disease involve acidic sphingomyelinase and ceramide. Nature Medicine, 13, 164-170
• Reinehr, R., Sommerfeld, A. & Häussinger, D. (2008) CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells. Gastroenterology 134, 1494-1506
• Görg, B., Qvartskhava, N., Keitel, V., Bidmon, H.J., Selbach, O., Schliess, F. & Häussinger, D. (2008) Ammonia induces RNA oxidation in cultured astrocytes and brain in vivo. Hepatology, 48, 567-579

Cooperators

• Lang, F., Prof. Dr., University of Tübingen, Germany
• Marschall, H.U., Prof. Dr., Karolinska Institute Stockholm, Sweden
• Paulmichl, M., Prof. Dr., University of Innsbruck, Austria
• Dienes, H.P., Prof. Dr., University of Cologne, Germany
• Krause, H.P., Prof. Dr., University of Geneva, Switzerland