Willbold Group

Group leader

Title	Name	First Name	Position
Prof. Dr.	Willbold	Dieter	Head of the Institute

 For more information on the principal investigator click here...

Researchers

Title	Name	First Name	Position
Dr.	Stoldt	Matthias	Senior Scientist
PD Dr.	König	Bernd	Senior Scientist
Dr.	Nagel-Steger	Luitgard	Senior Scientist

BioStruct Fellow

Title	Name	First Name	Position
MSc	Börger	Claudia	Doctoral Researcher

 For more information on the biostruct fellow click here...

Further Team Members

Technicians:	5
Master/Diploma students:	2
PHD/MD students:	17

Contact

Dieter Willbold
Institute of Physical Biology
Heinrich Heine University
Universitätsstr. 1
40225 Düsseldorf
Germany

+49(0)211-81-11390
+49(0)211-81-15167


website:
http://www.biologie.uni-duesseldorf.de/Institute/Physikalische_Biologie
http://www.fz-juelich.de/inb/inb-2/

Contact 2

Matthias Stoldt
Institute of Physical Biology
Heinrich Heine University
Universitaetsstr. 1
40225 Duesseldorf
Germany

+49(0)2461-61-5874
+49(0)2461-61-2023

Expertise in Structural Biology

• Liquid NMR-spectroscopy
• Fluorescence Correlation Spectroscopy (FCS)
• Analytical Ultracentrifugation
• Surface Plasmon Resonance Spectroscopy

 click here for further information

Main areas of research interest

• Structural biology
• NMR spectroscopy
• Protein ligand interactions
• Viral proteins (HIV and SARS-CoV) and their cellular interaction partners
• Proteins involved in neurodegeneration
• Approaches to diagnosis and therapy of Alzheimer's disease

Facilities

The laboratories cover the following gene technology security levels:	S1, S2
The laboratories cover the following biohazard levels:	BSL1, BSL2, BSL3**

Laboratory Equipment

General equipment available in the laboratories:

• Biochemistry
• Biophysics
• Cell culture
• Molecular biology
• Biotechnology
• Biocomputing
• Microbiology
• Imaging

Special equipment, which is not generally available in most laboratories:

• NMR-Spectrometers: 3x 600 MHz, 1x 800 MHz, 1x 900 MHz
• Analytical Ultracentrifuge
• Dual-Colour Fluorescence Correlation Spectrometer
• Surface Plasmon Resonance Spectrometer
• Circular Dichroism Spectrometer
• Fluorescence Spectrometer
• Confocal Laser Scanning Microscope
• Field Flow Fractionation with Multiangle Light Scattering Detection

Photo: NMR spectrometer

Non-standard methods, which are established in the laboratory

• Nanodisc Technology
• Phage Display Screening
• Mirror Image Phage Display Screening
• High Magentic Field NMR Spectrosocpy
• 2-Dimensional Fluorescence Intensity Distribution Assay (2D-FIDA)

Important References

• Willbold, D., Rosin-Arbesfeld, R., Sticht, H., Frank, R. & Rösch, P. (1994) Structure of the equine infectious anemia virus Tat protein. Science 264, 1584-1587
• Rösch, P. & Willbold, D. (1996) Is EIAV Tat protein a homeodomain? Science 272, 1672
• Schmidt, H., Hoffmann, S., Tran. T., Stoldt, M., Stangler, T., Wiesehan, K. & Willbold, D. (2007) Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes. J. Mol. Biol. 365, 1517-1532.
• Wittlich, M., König, B. W., Hoffmann, S. & Willbold, D. (2007) Structural characterisation of the transmembrane and cytoplasmic domains of human CD4. BBA Biomem. 3, 2949-2960.
• Weiergraeber, O. H., Stangler, T., Thielmann, Y., Mohrlüder, J., Wiesehan, K. & Willbold, D. (2008) Ligand binding mode of GABAA receptor-associated protein. J. Mol. Biol., 381, 1320-1331

Cooperators

• Gordeliy, Victor, Prof. Dr., CEA-CNRS-Université Joseph Fourier in Grenoble, France
• Korth, Carsten, PD Dr., Institut für Neuropathologie, Universtitätsklinikum Düsseldorf, Germany
• Schrader, Thomas, Prof. Dr., University Duisburg-Essen, Germany
• Sticht, Heinrich, Prof. Dr., Friedrich-Alexander University Erlangen-Nürnberg, Germany
• van Groen, Thomas, Prof. Dr., University of Alabama at Birmingham, USA