Heise Group

Group leader

Title	Name	First Name	Position
Prof. Dr.	Heise	Henrike	Head of the group

 For more information on the principal investigator click here...

Researchers

Title	Name	First Name	Position
Dr.	Müller	Henrik	PostDoc

BioStruct Fellow

Title	Name	First Name	Position
MSc	Do	Hoa Quynh	PhD student

 For more information on the biostruct fellow click here...

Further Team Members

Technicians:	0
Master/Diploma students:	0
PHD/MD students:	1

Contact

Henrike Heise
INB-2
Forschungszentrum JuelichWilhelm-Johnen-Strasse
52425 Juelich
Germany

+49(0)2461-61-4658
+49(0)2461-61-2023


website:
http://www.biologie.uni-duesseldorf.de/Institute/Physikalische_Biologie/Gruppen/Arbeitsgruppe_Heise

Contact 2

Henrike Heise
Institute of Physical Biology
Heinrich-Heine University
Universitaetsstr. 1
40225 Duesseldorf
Germany

telephone: +49(0)211-81-10810

Expertise in Structural Biology

• Solid-State NMR Spectroscopy

 click here for further information

Main areas of research interest

• Solid-State NMR Spectroscopy technique development
• Study of amyloid proteins

Laboratory Equipment

Special equipment, which is not generally available in most laboratories:

NMR spectrometers (one dedicated spectrometer operating at 600 MHz and 50% access to an 800 MHz spectrometer, and 33% access to another 600 MHz spectrometer) equipped with MAS probeheads for high-resolution solid-state NMR spectroscopy.

Non-standard methods, which are established in the laboratory:

Solid-State NMR-spectroscopy at high fields, technique development and application.

Important References

• Heise, H., Hoyer, W., Becker, S., Andronesi, O., Riedel, D. & Baldus, M. (2005). Molecular-level secondary structure, polymorphism, and dynamics of full-length α-synuclein fibrils studied by solid-state NMR. Proc. Natl. Acad. Sci. U.S.A. 102, 15871-15876.
• Heise, H., Seidel, K., Etzkorn, M., Becker, S. & Baldus, M. (2005). 3D NMR spectroscopy for resonance assignment and structure elucidation of proteins under MAS: novel pulse schemes and sensitivity considerations. J. Magn. Reson. 173, 64-74.
• Andronesi, O. C., Becker, S., Seidel, K., Heise, H., Young, H. S. & Baldus, M. (2005). Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy. J. Am. Chem. Soc. 127, 12965-12974.
• Heise, H. (2008). Solid-state NMR spectroscopy of amyloid proteins. ChemBioChem 9, 179-189.
• Heise, H., Celej, M. S., Becker, S., Riedel, D., Pelah, A., Kumar, A., Jovin, T. M. & Baldus, M. (2008). Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant α-synuclein. J. Mol. Biol. 380, 444-450.