Prof. Dr. Dieter Willbold

Institute of Physical Biology Heinrich Heine University Düsseldorf Universitätsstr. 1 40225 Düsseldorf +49(0)211-81-11390 +49(0)211-81-15167  website Institute of Physical Biology Institute of Complex Systems at Research Center Jülich c/o Institute of Complex Systems Strukturbiochemie (ICS-6) Research Center Jülich GmbH 52425 Jülich 49(0)2461-61-2100 49(0)2461-61-2023 website:  website ICS6 Jülich

Curriculum Vitae & Publications

 List of Publications

Expertise in Structural Biology

• Liquid NMR-spectroscopy

Main areas of research interest

• Structural biology
• NMR spectroscopy
• Protein ligand interactions
• Viral proteins (HIV and SARS-CoV) and their cellular interaction partners
• Proteins involved in neurodegeneration
• Approaches to diagnosis and therapy of Alzheimer's disease

Research Group and Equipment

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BioStruct Research Project

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Important references

• vanGroen T, Wiesehan K, Funke SA, Kadish I, Nagel-Steger L, Willbold D, Reduction of Alzheimer’s Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-enantiomeric Peptide Identified by Mirror Image Phage Display. ChemMedChem 3, 1848-1852 (2008).
• Schünke S, Stoldt M, Novak K, Kaupp UB, Willbold D. Solution structure of the M.loti K1 channel cyclic nucleotide binding domain in complex with cAMP. EMBO Rep. 10, 729-735 (2009).
• Glück JM, Wittlich M, Feuerstein S, Hoffmann S, König BW and Willbold D. Integral membrane proteins in nanodiscs can be studied by solution NMR spectroscopy. J. Am. Chem. Soc. 131, 12060-12061 (2009).
• Funke SA, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AHC, Müller-Schiffmann A, Korth C, Sticht H, Willbold D. Oral Treatment with the D-Enantiomeric Peptide D3 Improves Pathology and Behavior of Alzheimer’s disease Transgenic Mice. ACS Chem. Neurosci. 1, 639-648 (2010).
• Schünke S, Stoldt M, Lecher J, Kaupp UB, Willbold D. Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel. Proc. Natl. Acad. Sci. USA, 108, 6121-6126 (2011).

Cooperators

• Gordeliy, Victor, Prof. Dr., CEA-CNRS-Université Joseph Fourier in Grenoble, France
• Korth, Carsten, PD Dr., Institut für Neuropathologie, Universtitätsklinikum Düsseldorf, Germany
• Schrader, Thomas, Prof. Dr., University Duisburg-Essen, Germany
• Sticht, Heinrich, Prof. Dr., Friedrich-Alexander University Erlangen-Nürnberg, Germany
• van Groen, Thomas, Prof. Dr., University of Alabama at Birmingham, USA

Foto: Hanne Horn