Dr. Sander Smits

Institute of Biochemistry Membrane Transport Group Heinrich Heine University Düsseldorf Universitätsstr. 1 40225 Düsseldorf +49(0)211-81-12647 +49(0)211-81-15310   website

Curriculum Vitae & Publications

  List of Publications

Expertise in Structural Biology

• X-ray crystallography

Main areas of research interest

• ABC-transporters
• Lantibiotics/antimicrobial peptides
• Protein kinetics
• Protein modification
• Transport across membranes
  

Research Group and Equipment

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BioStruct Research Project

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Important reference

• Alkhatib Z,  Abts A, Mavaro A, Schmitt L and Smits SH (2012) Lantibiotics: How do producers become self-protected? J. Biotech in press
  

• Abts A, Mavaro A, Stindt J, Bakkes PJ, Metzger S, Driessen AJ, Smits SH, Schmitt L (2011) Easy and rapid purification of highly active nisin. Int J Pept 2011: 175145

• Mavaro A, Abts A, Bakkes PJ, Moll GN, Driessen AJ, Smits SH, Schmitt L (2011) Substrate recognition and specificity of NisB, the lantibiotic dehydratase involved in nisin biosynthesis. J Biol Chem  2;286(35):30552-60.

• Tschapek B, Pittelkow M, Sohn-Bosser L, Holtmann G, Smits SH, Gohlke H, Bremer E, Schmitt L (2011) Arg149 Is Involved in Switching the Low Affinity, Open State of the Binding Protein AfProX into Its High Affinity, Closed State. J Mol Biol 411: 36-52
  
  
• Smits SH, Meyer T, Mueller A, van Os N, Stoldt M, Willbold D, Schmitt L, Grieshaber MK (2010) Insights into the mechanism of ligand binding to octopine dehydrogenase from Pecten maximus by NMR and crystallography. PLoS One 5: e12312

Cooperators

• Gohlke, Holger Prof. Dr., University of Duesseldorf
• Bremer, Erhard Prof. Dr., University of Marburg
• Jäger, Karl Prof. Dr., University of Duesseldorf
• Driessen, Arnold Prof. Dr., University of Groningen
• Moll. Gert Dr., Biomade