Prof. Dr. Lutz Schmitt

Institute of Biochemistry Heinrich Heine University Düsseldorf Universitätsstr. 1 40225 Düsseldorf +49(0)211-81-10773 +49(0)211-81-15310  website

Curriculum Vitae & Publications

 List of Publications

Expertise in Structural Biology

• X-ray crystallography
• Fluorescence Spectroscopy

Main areas of research interest

• Structure and function of ABC-transporters
• Transport processes across biological membranes
• Protein-protein interaction
• Protein structure
• Recognition processes at membranes

Research Group and Equipment

 For detailed information click here...

BioStruct Research Project

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Important references

• L. Schmitt, H. Benabdelhak, M. A. Blight, I. B. Holland & M. T. Stubbs (2003) Crystal structure of the NBD of the ABC-transporter HlyB: Identification of a variable region within the ABC helical domains, J. Mol. Biol. 330 333-343.
• J. Zaitseva, S. Jenewein, T. Jumpertz, I. B. Holland, & L. Schmitt (2005) H662 is the linchpin in ATP hydrolysis of the nucleotide-binding domain of the ABC-transporter HlyB, EMBO J. 24 1901-1910.
• J. Zaitseva, C. Oswald, T. Jumpertz, S. Jenewein, A. Wiedenmann, I. B. Holland & L. Schmitt (2006) A structural analysis of asymmetry required for catalytic activity in an isolated ABC-ATPase domain dimer. EMBO J. 25 3432- 3443.
• C. Horn, S. Jenewein, B. Tschapek, W. Bouschen, S. Metzger, E. Bremer & L. Schmitt (2008) Monitoring conformational changes during the catalytic cycle of OpuAA, the ATPase subunit of the ABC-transporter OpuA from Bacillus subtilis, Biochem. J., 412 233- 244.
• R. Ernst, P. Kueppers, C. Klein, T. Schwarzmueller, K. Kuchler & L. Schmitt (2008) A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5 Proc. Natl. Acad. Sci USA 105 5069-5074.

Cooperators

• Holland, Barry, Prof. Dr., University of Paris-Sud, Orsay, France
• Kuchler, Karl, Prof. Dr., Medical University of Vienna, Austria
• Dötsch, Volker, Prof. Dr., University of Frankfurt, Germany
• Driessen, Arnold, Prof. Dr., University of Groningen, Netherlands
• Volkmer, Andreas, Dr., University of Stuttgart, Germany