Akad. Rat Dr. Filipp Oesterhelt

AG Nanoanalytik Institut für Physikalische Biologie Heinrich Heine Universität Düsseldorf Universitätsstr. 1 40225 Düsseldorf +49(0)211-81-13805 +49(0)211-81-15167 website:  http://www.mpc.uni-duesseldorf.de/nanoanalytik/index.htm

Curriculum Vitae & Publications

 List of Publications

Expertise in Structural Biology

• Atomic Force Microscopy
• Force Spectroscopy
• Single Molecule Fluorescence Spectroscopy

Main areas of research interest

• Membrane protein structure and stability
• Forces of ABC transporters
• Protein - RNA interactions
• nanopatterning of surfaces via nano-manipulation

Research Group and Equipment

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BioStruct Research Project

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Important references

• A. Woźniak, G. Schröder, H. Grubmüller, C. Seidel, F. Oesterhelt, " Single molecule FRET measures bends and kinks in DNA" PNAS, in press
• D.Cisneros, L. Oberbarnscheidt, A. Pannier, J. Klare, J. Helenius, M. Engelhard, F. Oesterhelt, D. J. Müller "Transducer binding establishes localized interactions that tune sensory rhodopsin II" Structure, Structure (2008) 16, 1206-13
• V. Kudryavtsev, S. Felekyan, A. Woźniak, M. König, C. Sandhagen, R. Kühnemuth, C. Seidel, F. Oesterhelt, "Multiparameter Fluorescence Imaging to Monitor Dynamic Systems". Anal Bioanal Chem (2007) 387, 71-82.
• A. Wozniak, S. Nottrott, E. Kühn-Hölsken, G. Schröder, H. Grubmüller, R. Lührmann, C. Seidel, F. Oesterhelt, "Detecting protein-induced folding of the U4 snRNA kink-turn by single-molecule multiparameter FRET measurements" RNA (2005) 11, 1545-1554.
• F. Oesterhelt, D. Oesterhelt, M. Pfeiffer, A. Engel, H. E. Gaub, D. J. Müller, "Unfolding pathways of individual Bacteriorhodopsins" Science (2000) 288, 143-146

Cooperators

• Müller, Daniel, Prof. Dr., University of Dresden, Germany
• Engelhard, Martin, Prof. Dr., Max Planck Institute for molecular physiology, Dortmund, Germany
• Rodnina, Marina, Prof. Dr., Max Planck Institute for biophysical Chemistry, Göttingen, Germany
• Wintermeier, Wolfgang, Prof. Dr., University Witten Herdecke, Germany
• Piehler, Jacob, Prof. Dr., University Osnabrück