Prof. Dr. Carsten Münk

AIDS Research Group Clinic for Gastroenterology, Hepatology and Infectiology University Hospital Düsseldorf Heinrich Heine University Düsseldorf Universitätsstr. 1 40225 Düsseldorf Germany  +49(0)211-81-10887

Publications

 List of Publications

Special Methodical Expertise

• Tissue culture of primary T cells and macrophages
• Quantification of HIV-replication by sensitive viral and cellular reporter systems

Main areas of research interest

• Structure and function of APOBEC3 proteins
• Evolution of retroviruses and co-evolution of antiviral genes
• Innate and intrinsic immunity against HIV-1
• Generation of animal models for HIV-1 infection

Research Group and Equipment

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BioStruct Research Project

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Important references

• Carsten Münk, T. Beck, J. Zielonka, A. Hotz-Wagenblatt, S. Chareza, M. Battenberg, J. Thielebein, K. Cichutek, I. G. Bravo, S. J. O’Brien, M. Löchelt*, and N. Yuhki*. 2008. Functions, Structure, and Read-Through Alternative Splicing of Feline APOBEC3 Genes. Genome Biology, 9 (3): R48
• Heide Muckenfuss, M. Hamdorf, U. Held, M. Perkovic, J. Löwer, K. Cichutek, E. Flory G. G. Schumann*, and C. Münk*. 2006. APOBEC3 proteins inhibit human LINE-1 retrotransposition. The J. of Biol. Chem. 281(31): 22161-22172.
• Martin Löchelt*, F. Romen, P. Bastone, H. Muckenfuss, N. Kirchner, Y. Kim, U. Truyen, U. Rösler, M. Battenberg, A. Saib, E. Flory, K. Cichutek, and C. Münk*. 2005. The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein. Proc. Natl. Acad. Sci. USA 102: 7982 – 7987
• Roberto Mariani, D. Chen, B. Schröfelbauer, F. Navarro, R. König, B. Bollman, C. Münk, H. Nymark-McMahon, and N. R. Landau. 2003. Species-specific exclusion of APOBEC3G from HIV-1 virions by VIF. Cell 114 (1):21-31.
• Carsten Münk, S. M. Brandt, G. Lucero, N. R. Landau. 2002. A dominant block to HIV replication at reverse transcription in simian cells. Proc. Natl. Acad. Sci. USA 99: 13843 – 13848.