Prof. Dr. Joachim Jose

Joachim Jose Bioanalytics Institute of Pharmaceutical and Medicinal Chemistry Universitätsstr. 1, Geb 26.23 02, R40 40225 Düsseldorf Germany +49(0)211 8113848 +49(0)211 8113847  website

Curriculum Vitae & Publications

 List of Publications

Special Methodical Expertise

• Surface Display of recombinant proteins in E. coli
• Membrane protein expression and preparation
• Biocatalytic synthesis by surface displayed enzymes
• Development of bioanalytic assays

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Main areas of research interest

• Evolutive drug design by surface display library screening
• Biocatalytic synthesis of drug or building blocks by whole cell biocatalysts with surface displayed enzymes
• Test assay development using whole cells of E. coli with surface displayed target proteins

See also:  http://www.pharmazie.uni-duesseldorf.de/Institute/pharm_chemie/Arbeitskreise/AK_Jose/Arbeitsgebiete

Research Group and Equipment

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BioStruct Research Project

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Important references

• Jose J, Jähnig F, Meyer TF (1995) Common structural features of IgA1-protease-like outer membrane protein autotransporters. Mol Microbiol 18: 380-382.
• Jose J, Betscheider D, Zangen D (2005) Bacterial Surface Display Library Screening by target enzyme labelling: Identification of New Human Cathepsin G Inhibitors. Anal Biochem, 346:258-267.
• Jose J, Meyer TF (2007) The autodisplay story – from discovery to biotechnical and biomedical applications. Microbiol Mol Biol R, 71:600-619
• Schultheiss E, Weiss S, Winterer E, Maas R, Heinzle E, Jose J (2008) Esterase autodisplay: enzyme engineering and whole cell activity determination by microplates with integrated pH-sensors. Appl Environ Microbiol, 74:4782-4791.
• Jose J, Chung JW, Jeon JB, Maas RM, Nam CH, Pyun JC (2009) E. coli with autodisplayed Z-domain of protein A for signal amplification of SPR biosensensor. Biosens Bioelectron, 24: 1324-1329.