Prof. Dr. Karl-Erich Jaeger

Institut für Molekulare Enzymtechnologie Forschungszentrum Jülich Stetternicher Forst 52426 Jülich Germany +49(0)2461-61-3716 +49(0)2461-61-2490 website:  http://www.iet.uni-duesseldorf.de/

Special Methodical Expertise

• enzyme gene identification – metagenomics
• protein expression systems
• large-scale (fermenter) protein production and purification
• protein engineering and directed evolution
• photochemistry of photoreceptor proteins

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Main areas of research interest

• Biotechnological applications of photoreceptor proteins
• Structure and function of flavin-binding photoreceptor proteins
• Photobiology and physiology of non-photosynthetic bacteria

Research Group and Equipment

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BioStruct Research Project

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Important references

• Drepper, T., T. Eggert, F. Circolone, A. Heck, U. Krauss, J. K. Guterl, M. ,Wendorff, A. Losi, W. Gärtner, and K. E. Jaeger. 2007. Reporter proteins for in vivo fluorescence without oxygen. Nat. Biotechnol 25:443-5.
• Krauss, U., A. Losi, W. Gartner, K. E. Jaeger, and T. Eggert. 2005. Initial characterization of a blue-light sensing, phototropin-related protein from Pseudomonas putida: a paradigm for an extended LOV construct. Phys Chem Chem Phys 7:2804-11.
• Becker, S., H. Hobenreich, A. Vogel, J. Knorr, S. Wilhelm, F. Rosenau, K. E. Jaeger, M. T. Reetz, and H. Kolmar. 2008. Single-cell high-throughput screening to identify enantioselective hydrolytic enzymes. Angew Chem Int Ed Engl 47:5085-8.
• Wilhelm, S., F. Rosenau, S. Becker, S. Buest, S. Hausmann, H. Kolmar, and K. E. Jaeger. 2007. Functional cell-surface display of a lipase-specific chaperone. Chembiochem 8:55-60.
• Tielker D, Eichhof I, Jaeger KE, Ernst JF. 2009 FMN-based fluorescent protein as an oxygen-independent reporter in Candida albicans and Saccharomyces cerevisiae. Eukaryot Cell, in press

Cooperators

• Losi, Aba, Dr., Department of Physics-University of Parma, Parma, Italy
• Gärtner, Wolfgang, Prof. Dr., Max-Planck-Institut für Bioanorganische Chemie, Mülheim, Germany
• von Haeseler, Arndt, Prof. Dr., Center for Integrative Bioinformatics, Vienna, Austria
• Benkovic, Stephen J., Prof. Dr., Department of Chemistry, Pennsylvania State University, USA