Prof. Dr. Johannes H. Hegemann

AG Hegemann Lehrstuhl für Funktionelle Genomforschung der Mikroorganismen Heinrich-Heine-Universität Düsseldorf Universitätsstr. 1, Geb. 25.02.U1 40225 Düsseldorf Germany +49(0)211 81-13733 +49(0)211 81-10637 website:  http://www.biologie.uni-duesseldorf.de/Institute/Funktionelle_Genomforschung

Curriculum Vitae & Publications

 Publications

Special Methodical Expertise

• protein purification
• Cell analysis + Cell sorting (FACSAria)
• Yeast molecular genetics
• Yeast 2-Hybrid arrays
• Yeast cellsurface display for the analysis of protein interactions

Main areas of research interest

• Genome stability
• Chromosome segregation
• Genome instability + ageing
• Chlamydia biology
• DNA mismatch repair system (MMR) in yeast + humans

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Research Group and Equipment

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BioStruct Research Project

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Important references

• Moelleken K, Hegemann JH.
  The Chlamydia outer membrane protein OmcB is required for adhesion and exhibits biovar-specific differences in glycosaminoglycan binding. Mol Microbiol. 2008 Jan;67(2):403-19
• Guldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH.
  Characterization of the Saccharomyces cerevisiae Fol1 Protein: Starvation for C1 Carrier Induces Pseudohyphal Growth. Mol Biol Cell. 2004 Aug;15(8):3811-28.
• Fiedler TA, Karpova TS, Fleig U, Young ME, Cooper JA, Hegemann JH. The vesicular transport protein Cgp1p/Vps54p/Tcs3p/Luv1p is required for the integrity of the actin cytoskeleton. Mol Genet Genomics. 2002 Oct;268(2):190-205.
• Giaever G, Chu AM, Ni L, Connelly C, Riles L, Veronneau S, Dow S, Lucau-Danila A, Anderson K, Andre B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Guldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kotter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M.
  Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002 Jul 25;418(6896):387-91.
• Guldener U, Heck S, Fielder T, Beinhauer J, Hegemann JH.
  A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res. 1996 Jul 1;24(13):2519-24.

Cooperators

• Prof. Dr. Roger Rank, Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, USA
• Prof. Dr. med. vet. Pospischil Andreas, Institut für Veterinärpathologie, Universität Zürich, Zürich, Switzerland
• Professor Dr. Alan P. Hudson, Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, USA
• Dr. Agathe Subtil, Institut Pasteur, Unité de Biologie des Interactions Cellulaires, Paris, France