Prof. Dr. Holger Gohlke

Holger Gohlke Institute of Pharmaceutical and Medicinal Chemistry Heinrich-Heine-University Universitaetsstr. 1 40225 Düsseldorf Germany +49(0)211-81-13662 +49(0)211-81-13847 website:  http://cpclab.uni-duesseldorf.de

Curriculum Vitae & Publications

 List of Publications

Expertise in Structural Biology

• Structural and molecular bioinformatics
• Molecular dynamics simulations
• Free energy calculations

 For detailed information click here...

Main areas of research interest

• Molecular recognition involving proteins and RNA as targets
• Protein-protein interactions
• Cotranslational processes in the ribosomal exit tunnel
• Linking biomacromolecular structure, dynamics, and function
• Development of structural and molecular bioinformatics tools

 See http://cpclab.uni-duesseldorf.de/research for more information.

Research Group and Equipment

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BioStruct Research Project

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Important references

• Gohlke, H., Kiel, C., Case, D. A. (2003). Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes. J. Mol. Biol., 330, 891-913.
• Gohlke, H., Thorpe, M. F. (2006). A natural coarse graining for simulating large biomolecular motion. Biophys. J., 91, 2115-2120.
• Fulle, S., Gohlke, H., (2008). Analyzing the flexibility of RNA structures by constraint counting. Biophys. J., 94, 4202-4219.
• Radestock, S., Gohlke, H. (2008). Exploiting the link between protein rigidity and thermostability for data-driven protein engineering. Eng. Life Science, 8, 507-522.
• Fulle, S., Gohlke, H. (2009). Statics of the ribosomal exit tunnel: Implications for co-translational peptide folding, elongation regulation, and antibiotics binding. J. Mol. Biol., 387, 502-517.

Cooperators

• Grez, Manuel, Dr., Georg-Speyer-Haus, Frankfurt, Germany
• Engels, Joachim, Prof. Dr., Goethe-University, Frankfurt, Germany
• Schwalbe, Harald, Prof. Dr., Goethe-University, Frankfurt, Germany
• Thorpe, Mike, Prof. Dr., Arizona State University, Tempe, AZ, USA