Dr. Melanie Brocker	Prof. Dr. Michael Bott
Melanie Brocker Institute of Biotechnology 1 Forschungszentrum Jülich GmbH Wilhelm-Johnen-Strasse 52428 Jülich Germany +49(0)2461-61-5168 +49(0)2461-61-2710  website	Michael Bott Institute of biotechnology 1 Forschungszentrum Jülich GmbH Wilhelm-Johnen-Strasse 52428 Jülich Germany +49(0)2461-61-3294 +49(0)2461-61-2710  website
Curriculum Vitae	Curriculum Vitae & Publications
	List of Publications

Special Methodical Expertise

• Transcriptomics using DNA microarray technology
• Proteomics including MALDI-TOF mass spectrometry
• Metabolic engineering

Main areas of research interest

• Elucidation of regulatory networks and mechanisms in biotechnologically relevant bacteria by studying transcriptional regulators, two-component signal transduction systems and serine/threonine protein kinases.
• Analysis of the energy metabolism in biotechnologically relevant bacteria by studying the respiratory chain and ATP-generating reactions.
• Development of microbial producer strains for amino acids, organic acids and other metabolites of industrial relevance using metabolic engineering

Research Group and Equipment

 For detailed information click here...

BioStruct Research Project

 For detailed information click here...

Important references

• Kaspar, S., Perozzo, R., Reinelt, S., Meyer, M., Pfister, K., Scapozza, L., and Bott, M. (1999) The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor. Mol. Microbiol. 33, 858-872.
• Niebisch, A. and Bott, M. (2003). Purification of a cytochrome bc1-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunit of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1. J. Biol. Chem. 278: 4339-4346.
• Wennerhold, J., Krug, A. and Bott, M. (2005). The AraC-type regulator RipA represses aconitase and other iron proteins from Corynebacterium under iron limitation and is itself repressed by DtxR. J. Biol. Chem. 280, 40500-40508
• Niebisch, A., Kabus, A., Schultz, C., Weil, B. and Bott, M. (2006). Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI protein. J. Biol. Chem. 281, 12300-12307
• Frunzke, J., Engels, V., Hasenbein, S., Gätgens, C. and Bott, M. (2008). Coordinated regulation of gluconate catabolism and glucose uptake in Corynebacterium glutamicum by two functionally equivalent transcriptional regulators, GntR1 and GntR2. Mol. Microbiol. 67, 305-322

Cooperators

• Eikmanns, Bernd, Prof. Dr., University of Ulm, Germany
• Bramkamp, Marc, Dr., University of Cologne, Germany
• Wendisch, Volker, Prof. Dr., University of Münster, Germany
• Burkovski, Andreas, Prof. Dr., University of Erlangen-Nürnberg, Germany
• Pohl, Ehmke, Dr., University of Durham, U.K.