PD Dr. Johannes Bode

Bode Department of Gastroenterology, Hepatology and Infectiology University Hospital of the Heinrich-Heine University Moorenstrasse 5 40225 Düsseldorf Germany +49(0)211-8118952 +49(0)211-8117517 website:  http://www.uniklinik-duesseldorf.de/gastroenterologie

Curriculum Vitae & Publications

Special Methodical Expertise

• Investigation of cellular signal-transduction using for example siRNA based techniques
• Methods to analyse transcriptional gene regulation such as Chromatin immunoprecipitation (ChIP)
• Analysis of protein/protein interaction using methods such as a pull down assays
• Imaging techniques based on confocal laser scanning microscopy or life cell imaging

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Main areas of research interest

• Control of macrophage activity during inflammation through the cross-talk of cytokine-/pathogen-induced intracellular signal-transduction cascades
• Influence of pathogen derived factors such as viral proteins or bacterial wall components on host cell signaling and assessment of the functional consequences A) for the host cell and B) for the pathogen
• Analysis of the hepatic acute phase response on systems biology level

Research Group and Equipment

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BioStruct Research Project

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Important references

• Brenndörfer, E. D., Karthe, J., Frelin, L., Cebula, P., Erhardt, A., Schulte am Esch, J., Hengel, H., Bartenschlager, R., Sällberg, M., Häussinger, D. & Bode, J.G. (2009). The hepatitis C virus non-structural 3/4A protease activates EGF-induced signal-transduction by cleavage of the T-cell protein tyrosine phosphatase. Hepatology in press
• Albrecht, U., Yang, X.P. Asselta, Keitel, V., Tenchini, M.L., Ludwig, S., Heinrich, P.C., Häussinger, D., Schaper, F., & Bode, J.G. (2007). Activation of NF-kappaB by IL-1beta blocks IL-6-induced sustained STAT3 activation and STAT3-dependent gene expression of the human gamma-fibrinogen gene. Cell Signal 19, 1866-1878
• Ehlting, C., Lai, W.S., Schaper, F., Brenndörfer, E.D., Matthes, R.J., Heinrich, P.C ., Ludwig, S., Blackshear, P.J., Gaestel, M., Häussinger, D., & Bode, J.G. (2007). Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. J Immunol 178,2813-2826.
• Bode, J. G., Schweigart, J. ,Kehrmann, J., Ehlting, C., Schaper, F., Heinrich, P.C. & Häussinger, D. (2003). TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex. J Immunol 171,257-266.
• Bode, J. G., Nimmesgern, A., Schmitz, J., Schaper, F., Schmitt, M., Frisch, W., Häussinger, D., Heinrich, P.C. & Graeve, L. (1999). LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages. FEBS Lett 463,365-370

Contact

NRW Research School BioStruct

Chairmen:
Prof. Dr. Lutz Schmitt


Prof. Dr. Dieter Willbold


Managing Director:
Dr. Christian Dumpitak


Scientific Coordinator:
Dr. Cordula Kruse



c/o
Institut für Physikalische Biologie
Heinrich-Heine-Universität Düsseldorf
Geb. 26.12.U1
Universitätsstr. 1
40225 Düsseldorf
Germany

+49-211-81-15314/14826
+49-211-81-14030