PD Dr. Reza Ahmadian

AG Ahmadian Institute of Biochemistry and Molecular Biology II University Hospital Düsseldorf Universitätsstr. 1, Building 22.03 40225 Düsseldorf +49(0)211-81-12384 +49(0)211-81-12726   website Ahmadian Gruppe:

Curriculum Vitae & Publications

 List of Publications

Expertise in Structural Biology

• Fluorescence Spectroscopy
• X-ray crystallography
• Computational biology

Main areas of research interest

• Control mechanisms of small GTPases
• Structure, Regulation and function of tumor-relevant regulators of small GTPases
• Biomolecular Network Reconstruction of the Rho GTPase signalling at the membrane
• α-helical peptidomimetics in protein-protein interaction

Research Group and Equipment

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BioStruct Research Project

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Important references

• Hemsath, L., Dvorsky, R., Fiegen, D., Carlier, M.F. & Ahmadian, M.R. (2005). An Electrostatic Steering Mechanism of Cdc42 Recognition by Wiskott-Aldrich Syndrome Proteins. Mol Cell 20, 313-324
• Hemsath, L. and Ahmadian, M.R. (2005). Fluorescence approaches for monitoring interactions of RhoGTPases with nucleotides, regulators and effectors. Methods 37, 173-182
• Dvorsky, R., Blumenstein, L., Vetter, I.R. & Ahmadian, M.R. (2004). Structural insights into the interaction of ROCKI with the switch regions of RhoA. J. Biol. Chem. 279, 7098-7104
• Fiegen, D., Haeusler, L.C., Blumenstein, L., Herbrand, U., Dvorsky, R., Vetter, I.R. & Ahmadian, M.R. (2004). Alternative splicing of Rac1 creates a self-activating GTPase. J Biol Chem 279, 4743-4749
• Ahmadian, M.R., Zor, T., Vogt, D., Kabsch, W., Selinger, Z., Wittinghofer, A. & Scheffzek, K. (1999). Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc Natl Acad Sci USA 96, 7065-7070

Cooperators

• Carlier, Marie-France, Laboratoire d'Enzymologie, C.R.N.S., Gif-sur-Yvette, France
• McMahon, Harvey T., MRC Laboratories, Cambridge, UK
• Scheffzek, Klaus, EMBL, Strukturelle Biologie-Programme, Heidelberg
• Wittinghofer, Alfred, Max-Planck Institut für molekulare Physiologie, Dortmund