Mr. Mario Schneider

Oesterhelt Group Institute for physical Chemistry II Heinrich Heine University Universitätsstr.1, Geb. 26.12.U1.78 40225 Düsseldorf, Germany  +49(0)211-81-14923

Mini Academic CV

University degrees:

First degree or intermediate examination:

• B.Sc. 2008, University of Applied Sciences Niederrhein, Krefeld, Germany

Second degree and/or intermediate examination:

• M.Sc. 2010, University of Applied Sciences Niederrhein, Krefeld, Germany

Publications:

• Schram, Juergen, Schneider, Mario, Horst, Rasmus and Thieme, Hagen (2009); Antiquarian books as source of environment historical water data.; J. Environ. Monit., 2009, 11, 1101-1106.

Attended conferences:

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Prices/Scholarships:

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BioStruct PhD project

Analysis of oligomeric amyloid beta structures with single molecule fluorescence spectroscopy and FRET
he amyloid beta peptide originates from specific cleavage of the APP (amyloid beta precursor protein). It aggregates to linear fibrils and is the main component of the amyloid beta plaques found in the brain of Alzheimer patients. However, recent results indicated that amyloid beta oligomers may be the main factor for neurotoxicity and the degradation of the brain. We apply single molecule FRET (fluorescence resonance energy transfer) to study the process of early amyloid beta aggregation. This allows us to measure accurate inter and intramolecular distances between fluorescently labeled amyloid beta peptides with sub nanometer accuracy. Thus the measured distances reveal the structure of the amyloid beta particles and their conformational changes during the early process of aggregation. The aim of this project is to provide a thorough characterization of the toxic oligomeric amyloid beta particles required for further studies on structural changes of the particles in CSF and the presence of new drug candidates..


Topic Supervisor: Prof. Dr. Filipp Oesterhelt, Institut für Physikalische Chemie II, Heinrich Heine Universität Düsseldorf, Oesterhelt Group

Complementary Supervisor: Prof. Dr. Lutz Schmitt, Institut für Biochemie, Heinrich Heine Universität Düsseldorf, Schmitt Group

BioStruct Fellow: Mr. Mario Schneider

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