Ms. Raj Rani
Institut für Molekulare Enzymtechnologie
Stetternicher Forst, 15.8, level 2, room 403
52426 Jülich, Germany
Mini Academic CV
University degrees:First degree or intermediate examination:
- BSc (Botany, Zoology, Chemistry), 2004, Punjabi University, Patiala, India
- MSc (Biotechnology), 2006, Hemwati Nandan Bahuguna Garhwal University, Rishikesh, India
- International conference on "Open source for computer aided drug discovery"(OSCADD), March 2009 organized by Institute of Microbial Technology(IMTECH), Chandigarh, India.
BioStruct PhD projectBlue-light activated LOV-photoswitches and their biotechnological applications
This project aims to evaluate the potential of bacterial photoreceptors of the light, oxygen, voltage (LOV)-family to generate genetically-encoded biocatalyst-photoswitches, which allow for the light-dependent modulation of enzyme activities (properties) at will. To provide a rational basis for the engineering of such switches, biomolecular NMR will be used to study the signal-transduction mechanism in bacterial LOV-proteins. The main focus-point will be the unfolding or dissociation of LOV-domain C-terminal helical extensions, which have previously, in plant LOV-systems, been suggested to unfold upon light excitation. This light-dependent conformational change allows in the plant-system to trigger the activity in LOV-associated effector domains.
Topic Supervisor: Prof. Dr. Karl-Erich Jaeger, Institut für Molekulare Enzymtechnolgie, Jaeger Group
Complementary Supervisor: Prof. Dr. D. Willbold, Institute for physical biology, Willbold Group
Complementary Supervisor: Dr. Ulrich Krauss, Institut für Molekulare Enzymtechnolgie, FZ Jülich
BioStruct Fellow: Ms. Raj Rani
Last updated: 22.11.2012, 14:19