Mr. Badri Nath Dubey

Ahmandian Group Institute of Biochemistry and Molecular Biology II Heinrich Heine University Universitätsstr.1, Geb. 22.03 40225 Düsseldorf, Germany  +49(0)211-81-10854

Mini Academic CV

University degrees:

First degree or intermediate examination:

• BSc(Chemistry, Botany, Zoology), 2003, Allahabad University, Allahabad, India

Second degree and/or intermediate examination:

• MSc(Molecular Biology and Biotechnology), 2006, Tezpur University, Tezpur Assam, India

Postgraduate degree

• Dr. rer. nat. 2012, Heinrich Heine University, Duesseldorf, Germany
  

Publications:

• Ranjan A., Sinha A. Y., Dubey, B., Saikia, A., Buragohain A. K. and Ray S. K. (2008) Analysis of bacterial genomes for In-frame dinucleotide abundance, abundance of the encoded amino acids and synonymous codon choice reveals a common pattern. Current science, 94 no.2
• Dubey, B., Buragohain, A. K. and Ray, S.K. (2008). A positive correlation between the number of transfer RNA genes with different anticodons and bacterial genome G + C %. The ICFAI journal of Biotechnology.

Attended conferences:

• Participated in ACT-X (Tenth Asian conference on Transcription) January ,2008 held in Indian Institute of Science, Bangalore, India.

Prices/Scholarships:

• National scholarship, funded by Government of Utter Pradesh India (1995-1997).
• Scholarship from Department of Biotechnology (DBT) under Ministry of science and technology Government of India (2004-2006).
• GATE qualified in 2006 with 93 percentile in life science(XL) conducted by Indian institute of Technology (I.I.T), Kharagpur.

BioStruct PhD project

Mechanisms of regulation and activation of Rho-effectors
The GTP-binding proteins of the Rho-Family regulate a spectrum of functionally diverse downstream effectors e.g. Rho kinase (ROCK) and thus initiate a variety of cellular processes, ranging from cytoskeleton reorganization to gene transcription. Our interest in the Rho/ROCK pathway as a target for therapeutic interventions comes from the observation on its involvement in tumor invasion and in diseases such as hypertension and bronchial asthma. However, important questions such as (i) How ROCK activation is achieved by RhoA, (ii) how ROCK is integrated in the signaling complexes at the lipid membrane and (iii) how other small GTPases such as Gem/Rad and Rnd3 interact with ROCK and thus antagonize Rho-ROCK signaling, remained to be answered. Our recent data support the notion of multiple effector binding sites in RhoA and strongly indicate the existence of a cooperative binding mechanism for ROCK that may be the molecular basis of Rho-mediated effector activation. To corroborate this working hypothesis we have planned to study comprehensively the structure-function relationship of RhoA interaction with full length and various fragments of ROCK. Furthermore we will analyze ROCK regulation by various small GTPase including RhoA, Gem, Rad and Rnd proteins using biochemical methods and X-Ray crystallography. Finally, we will search for additional ROCK binding partners in a proteomic approach using full length ROCK. Alongside the fundamental signal transduction mechanisms, expected results will be crucial for rational drug development.


Topic Supervisor: PD Dr. Mohammad Reza Ahmadian, Institute for Biochemistry and Molecular Biology II, Heinrich Heine University Duesseldorf, Ahmandian Group

Complementary Supervisor: Prof. Dr.Georg Groth, Institute for Plant Biochemistry, Heinrich Heine University Duesseldorf, Groth Group

BioStruct Fellow: Mr. Badri Nath Dubey

Foto: Hanne Horn