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Prof. Dr. R. Mannhold, Dr. H. Lemoine: Molecular Drug Research
 

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Reviewed Publications:

  1. Lemoine H, Weber H, Derix A, Uhrig U, Höltje, H.-D, Mannhold R (1999) 6-varied benzopyrans: vasodilator activity in rat aorta and trachea, QSAR analysis; conversion to muscarinic antagonists. Eur. J. Pharmacol., 378, 85-97
  2. Mannhold R, Cruciani G, Weber H, Lemoine H, Derix A, Weichel C, Clementi M (1999) 6-varied benzopyrans as potassium channel activators: synthesis, vasodilator properties and multivariate analysis. J. Med. Chem., 42, 981-991
  3. Teschemacher A, Lemoine H (1999) Kinetic analysis of drug-receptor-interactions of long acting ß2-sympathomimetics in isolated receptor membranes. Evidence against prolonged effects of salmeterol and formoterol on receptor coupled adenylyl cyclase. J Pharmacol Exp Ther, 288, 1084-1092
  4. Reinhardt D, Berdel D, Griese M, Küster H, Lecheler J, Lemoine H, von Mutius E, Nicolai T, Petermann F (1999) Asthma bronchiale im Kindesalter. 3., aktualisierte und erweiterte Auflage, Springer Verlag, Berlin, Heidelberg, New York
  5. Mannhold R, Rekker RF (1999) The hydrophobic fragmental constant approach for calculating log P in octanol/water and aliphatic hydrocarbon/water systems. Perspectives in Drug Discovery and Design, in the press
  6. Dross K, Rekker RF, de Vries G, Mannhold R (1998) The lipophilic behaviour of organic compounds. 3. The search for interconnections between reversed-phase chromatographic data and log Poct values. Quant. Struct.-Act. Relat., 17, 549-557
  7. Mannhold R, Cruciani G, Dross K, Rekker RF (1998) Multivariate analysis of experimental and calculative descriptors for molecular lipophilicity. J. Comp.-Aid. Mol. Design, 12, 573-581
  8. Mannhold R, Rekker RF, Dross K, Bijloo G, de Vries G (1998) The lipophilic behaviour of organic compounds. 1. An updating of the hydrophobic fragmental constant approach. Quant. Struct.-Act. Relat., 17, 517-536
  9. Rekker RF, Mannhold R, Bijloo G, de Vries G, Dross K (1998) The lipophilic behaviour of organic compounds. 2. The development of an aliphatic hydrocarbon/water fragmental system via interconnection with octanol-water partitioning data. Quant. Struct.-Act. Relat., 17, 537-548
  10. Teschemacher A, Reinhardt D, Lemoine H (1998) Do parasympatholytic effects of long-acting ß2-sympathomimetics contribute to their beneficial effects in the therapy of bronchial asthma? Pulmonary Pharmacol Ther, 11, 253-261
  11. Caldirola P, Monteil A, Zandberg P, Mannhold R, Timmerman H (1997) VUF 8929, a diphenylalkylamine derivative with selective coronary dilatory properties. Arzneim. Forsch. - Drug Res. 47, 1211-1218
  12. Weiss M, Schneider EM, Liebert S, Mettler S, Lemoine H (1997) Vasoactive drugs inhibit oxygen radical production of neutrophils. Immunopharmacology and Immunotoxicology 19(2), 239-263
  13. Mannhold R, Dross K, Sonntag C (1996) Estimation of lipophilicity by reversed-phase thin-layer chromatography. In: Lipophilicity in Drug Action and Toxicology (eds. V. Pliska, B. Testa, H. van de Waterbeemd), Methods and Principles in Medicinal Chemistry, vol. 4, VCH publishers, 140-156
  14. Mannhold R, Dross K (1996) Calculation procedures for molecular lipophilicity: a comparative study. Quant. Struct.-Act. Relat. 15, 403-409
  15. van de Waterbeemd H, Mannhold R (1996) Calculation programs for log P values. Quant. Struct.-Act. Relat. 15, 410-412
  16. van de Waterbeemd H, Mannhold R (1996) Lipophilicity descriptors for structure-property studies: Overview of experimental and theoretical methods and a benchmark of log P calculations. In: Lipophilicity in Drug Action and Toxicology (eds. V. Pliska, B. Testa, H. van de Waterbeemd), Methods and Principles in Medicinal Chemistry, vol. 4, VCH, 401-418
  17. Weiss M, Schneider EM, Tarnow J, Mettler S, Krone M, Teschemacher A, Lemoine H (1996) Is inhibition of oxygen radical production of neutrophils by symphathomimetics mediated via ß2-adrenoceptors? J Pharmacol Exp Ther 278, 1105-1113
  18. Mannhold R, Rekker RF, Sonntag C, ter Laak A, Dross K, Polymeropoulos EE (1995) Comparative evaluation of the predictive power of calculation procedures for molecular lipophilicity. J. Pharm. Sci. 84, 1410-1419
  19. Voigt W, Romanelli N, Lemoine H, Mannhold R, Dei S, Teodori E, Gualtieri F (1995) Structural dependence of the allosteric interaction of semi-rigid verapamil analogues with DHP-binding in kitten heart. Eur. J. Pharmacol. - Mol. Pharmacol. Section 291, 255-264
  20. Zink S, Rösen P, Lemoine H (1995) Comparison of micro- and macrovascular endothelial cells (BREC and BAEC) in ß-adrenergic regulation of transendothelial permeability. Am J Physiol 269 (Cell Physiol 38), C1209-C 1218
  21. Dross K, Sonntag C, Mannhold R (1994). On the estimation of the hydrophobicity parameter RMw by reversed-phase thin-layer chromatography. J Chromatogr 673: 113-124 
  22. Mannhold R (1994). Medicinal chemistry of DHP-like Ca-antagonists. Drugs of Today 30: 103-122 
  23. Romanelli MN, Dei S, Scapecchi S, Teodori E, Gualtieri F, Budriesi R, Mannhold R (1994). Semi-rigid analogues of the calciumantagonist verapamil: a molecular modelling study. J Comp-Aid Mol Design 8: 123-134 
  24. Teodori E, Dei S, Romanelli MN, Scapecchi S, Gualtieri F, Budriesi R, Chiarini A, Lemoine H, Mannhold R (1994). Synthesis and pharmacological evaluation of verapamil analogs with restricted molecular flexibility. Eur J Med Chem 29: 139-148 
  25. Caldirola P, Coats E, Mannhold R, van der Goot H, Timmerman H (1993). New calmodulin antagonists of the diphenylalkylamine type. II. QSAR investigations by means of PLS analysis. Eur J Med Chem 28: 783-790 
  26. Caldirola P, Zandberg P, Mannhold R, Timmerman H (1993). New prenylamine analogues: investigations of their influence on calcium-dependent biological systems. Eur J Med Chem 28: 555-568 
  27. Dei S, Romanelli MN, Scapecchi S, Teodori E, Gualtieri F, Chiarini A, Voigt W, Lemoine H (1993). Verapamil analogues with restricted molecular flexibility: Synthesis and pharmacological evaluation of the four isomers of alpha-[1-[3[N-[1-[2- (3,4 dimethoxyphenyl) ethyl]]-N-methylamino]cyclohexyl]]-alpha-isopropyl-3,4- dimethoxybenzene-acetonitrile. J Med Chem 36: 439-445 
  28. Dross K, Sonntag C, Mannhold R (1993). On the precise estimation of RM-values in reversed-phase TLC including aspects of pH-dependence. J Chromatogr 639: 287-294 
  29. Lemoine H, Worth H, Reinhardt D (1993). Pharmakologische Charakterisierung von Formoterol im Vergleich zu Isoproterenol, Fenoterol und Salbutamol an Trachealmuskelstreifen und Lungenmembranen des Meerschweinchens. Pneumologie 47: 303-310 
  30. Mannhold R, Caldirola P, Bijloo GJ, Timmerman H (1993). New calmodulin antagonists of the diphenylalkylamine type. I. Biological activity, SAR and lipophilicity-dependence of action. Eur J Med Chem 28: 727-734 
  31. Rekker RF, Mannhold R, ter Laak AM (1993). On the reliability of calculated log P-values: Rekker-, Hansch/Leo- and Suzuki-approach. Quant Struct-Act Relat 12: 152-157 
  32. Zink S, Rösen P, Sackmann B, Lemoine H (1993). Regulation of endothelial permeability by ß-adrenoceptor agonists: contribution of ß1- and ß2-adrenoceptors. Biochim Biophys Acta 1178: 286-298 
  33. Caldirola P, Mannhold R, Timmerman H (1992). Calmodulin and calmodulin- antagonists. Current Opin Ther Patents 2: 1889-1917 
  34. Dross K, Mannhold R, Rekker RF (1992). Drug lipophilicity in QSAR practice. II. Aspects of RM-determinations and their interrelations with partition coefficients. Quant Struct-Act Relat 11: 36-44 
  35. Lemoine H (1992). ß-Adrenoceptor ligands: characterization and quantification of drug effects. Quant Struct Act Relat 11: 211-218 
  36. Lemoine H, Overlack C (1992). Highly potent ß2-sympathomimetics convert to less potent partial agonists as relaxants of guinea-pig tracheae maximally contracted by carbachol. Comparison of relaxation with receptor binding. J Pharmacol Exp Ther 261: 258-270 
  37. Lemoine H, Overlack C, Köhl A, Worth H, Reinhardt D (1992). Formoterol, fenoterol and salbutamol as partial agonists for relaxation of maximally contracted guinea-pig tracheae. Comparison of relaxation with receptor binding. Lung 170: 163-180 
  38. Mannhold R (1992). Calmodulin antagonists: chemistry, molecular pharmacology and therapeutic applications. Drugs of the Fut 28: 175-199 
  39. Mannhold R (1992). University drug research: current state and future perspectives. Quant Struct-Act Relat 11: 232-236 
  40. Mannhold R, Jablonka B, Voigt W, Schönafinger K, Schraven E (1992). Calcium- and calmodulin-antagonism of elnadipine derivatives: a comparison of structure-activity relationships. Eur J Med Chem 27: 229-235 
  41. Mannhold R, Timmerman H (1992). Putative therapeutic applications of calmodulin antagonists. Pharmaceut Weekblad, Scientific Edition 14: 161-166 
  42. Overlack C, Lemoine H, Worth H, Reinhardt D (1992). Vergleichende Analyse der kardialen Nebenwirkungen von ß2-Sympathomimetika im Tiermodell. Atemw-Lungenkrkh 18: 316-317 
  43. Wasner HK, Kaufmann R, Lemoine H (1992). Mass spectrometric identification of prostaglandyl-inositol, the dephosphorylated cyclic AMP antagonist, cyclic PIP. Analusis 20: 171-177 
  44. Lemoine H., Kaumann A.J.:Regional differences of ß1- and ß2-adrenoceptor-mediated func-tions in feline heart. A ß2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP.Naunyn-Schmiedeberg's Arch. Pharmacol. 344, 56- 69, 1991 
  45. Worth H., Lemoine H., Overlack C., Reinhardt D.:ß1-/ß2-Subtypselektivität und Abhängigkeit der Wirksamkeitverschiedener ß2-Sympathomimetika von der muskarinergen Vor-stimulation isolierter Trachealmuskelstreifen.Atemwegs- und Lungenkrkh. 17, 419- 420, 1991 
  46. Lemoine H.:ß-Rezeptorsubtypen: Funktionelle Aspekte der Wirkung von Adrenalin und Noradrenalin über adrenerge Rezeptoren des Herzens und des Trachealmuskels von Tier und Mensch.Verlag Haag & Herchen, Frankfurt/Main, 1990 

Non-Reviewed Publications: 

Talks:

Dissertations:

  1. Voigt, W. (1992) Klasse I-Antiarrhythmika. Medizinisch-chemische und molekularpharmakologische Charakterisierung. 
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