Job Positions:
I have opened a new Career related site called The BIOCareer Center
(http://www.biocareer.com). This site created and designed by SciWeb
(http://www.sciweb.com) in collaboration with the Biotechnology Industry
Organization - BIO - (http://www.bio.org) is intended to be a growing resource
center for anyone working in the Biotechnology industry.
The site now has a searchable database of Jobs and a database into which you
can post your Resume or CV for free.
There is also a Career Oriented Discussion Board for the industry, a Salary
Survey database and a Web Directory. Additional resources are planned for the
future.
Check it out and let me know if this site meets your needs.
webmaster@biocareer.com
11 Jun 1998
Postdoc position - signal transduction & transcription
Applications are invited for postdoctoral positions in a newly
established research group at the Ludwig Institute for Cancer Research
(LICR) in Uppsala, Sweden. The successful candidates will study the
transcriptional regulation of metabolic pathways and the transcriptional
mechanisms of growth factor signal transduction (Ericsson et al. (1996)
Proc. Natl. Acad. Sci. U.S.A. 93, 945-950; Ericsson et al. (1996) J.
Biol. Chem., 271, 24359-24367; Ericsson and Edwards. (1998) J. Biol.
Chem., in press; Heldin et al. (1997) Nature, 390, 465-471; Dennler et
al. (1998) EMBO J., 17, 3091-3100). The aim is to identify the
downstream targets (i.e. transcription factors, coactivators and
corepressors) of these signaling pathways and to determine how these
molecules regulate gene expression. We are also interested in how
abnormal regulation of these processes is related to the development of
human disease. We are seeking highly motivated scientists (Ph.D./M.D.)
with strong backgrounds in molecular and cellular biology, gene
expression, transcriptional regulation and signal transduction. Funding
is available from the Ludwig Institute for Cancer Research and the
Swedish Natural Science Research Council. However, candidates will also
be encouraged to apply for external awards and fellowships. The
positions are available starting October, 1998.
The Ludwig Institute for Cancer Research is an international
organization which uses a multi-disciplinary approach to study cell
growth, differentiation and cancer. The Uppsala branch is located within
the Biomedical Center at the University of Uppsala. The institute has
exceptional facilities and offers the opportunity to work with leading
scientists in an international and team-oriented environment. For more
information, please visit our website:
http://www.licr.uu.se
If you want to join a highly motivated research group, please forward
your curriculum vitae, a brief description of your research experiences
and the names and addresses of three references to (e-mail or fax
preferred):
Before July 21, 1998:
Johan Ericsson, Ph.D.
Department of Medicine
Division of Cardiology
UCLA School of Medicine
47-123 CHS
Los Angeles, CA 90095
USA
Fax: 1 310 794 7345
E-mail: ericsson@biovx1.biology.ucla.edu
After July 21, 1998:
Johan Ericsson, Ph.D.
Ludwig Institute for Cancer Research
Biomedical Center
Box 595
S-751 24 Uppsala
Sweden
Fax: 46 18 16 04 20
24 Jun 1998
RESEARCH ASSOCIATE/POSTDOCTORAL FELLOW
Postdoctoral opportunities to study molecular mechanisms of immune evasion
by microbial pathogens, with emphasis on Trypanosoma cruzi and Pneumocystis
pneumoniae. Projects include molecular analysis of virulence factors,
characterization of the immune response to vaccine candidates, molecular
modeling of membrane proteins involved in immune evasion, use of
combinatorial peptide and immunoglobulin libraries for the generation of
immunotherapeutic reagents, design of DNA vaccines and bacterial antigen
delivery systems as vaccine vehicles.
QUALIFICATIONS:
Ph.D. in microbiology, immunology or related fields.
Position requires microbiologic/immunologic background and experience in
molecular biology and/or protein biochemistry. Experience in cell culture,
PCR, electrophoresis, molecular biological and immunological techniques is
helpful.
ADDITIONAL RESPONSIBILITIES INCLUDE:
Supervision of research associates and graduate students
Writing manuscripts and participation in preparing research proposals
Utilization of computer software for nucleic acid and protein analysis, word
processing, routine statistical analysis, graphics, and communications.
APPLICATIONS:
Forward curriculum vitae,
description of research interests and goals, and the names, addresses,
and phone numbers of three references to:
Dr. Karen A. Norris
Department of Molecular Genetics and Biochemistry
University of Pittsburgh School of Medicine
E1240 Biomedical Science Tower
Pittsburgh PA 15261
email: kan1@vms.cis.pitt.edu
fax: (412) 624-1401
website: http://www.pitt.edu/~rsup/mgb/norrislab.html
Karen A. Norris, Ph.D.
Department of Molecular Genetics and Biochemistry
E 1240 Biomedical Science Tower
University of Pittsburgh School of Medicine
Pittsburgh, PA 15261
Phone: (412) 648-8848
Fax: (412) 624-1401
email: kan1@vms.cis.pitt.edu
30 Jun 1998
POSITION TITLE: Assistant/Associate Professor- Molecular Genetics and
Breeding (Wheat)
LOCATION: Department of Plant and Soil Sciences
Oklahoma State University
POSITION DESCRIPTION:
This is an 11-month, tenure-track, research/teaching position.
(Approximately 90% research and 10% teaching.)
RESEARCH RESPONSIBILITIES: Develop a state-of-the-art applied
wheat genomics program that will enhance phenotypic-based
selection efficiency by use of molecular markers. Use of
currently identified marker associations and development of new
linkages is expected. Targeted traits may include, but are not
limited to, value-added grain quality, pest resistance,
pharmaceutical-nutritive value of forage, and stress tolerance,
particularly adaptation to low-pH soils. Adaptation of genomics
to develop hard red and hard white winter wheat varieties targeted
for dual-purpose (graze-plus-grain) and grain-only production
systems is essential. Use of genomics to pursue related areas of
research in genome organization, gene isolation, development of
improved molecular techniques applicable to wheat improvement,
or wheat molecular cytogenetics is encouraged.
An ability to obtain extramural funding is essential. Effective
interaction with the wheat breeder and other members of the Wheat
Improvement Team (http://clay.agr.okstate.edu/wheat/wit.html)
specializing in pathology, entomology, management, physiology,
transformation, and cereal chemistry is essential.
TEACHING RESPONSIBILITIES: Team-taught graduate course in plant
breeding principles and development of a graduate-level course
in the candidate's area of specialization. Graduate student
advisement and participation in graduate committees is expected.
SALARY AND BENEFITS: Will be competitive with other leading land
grant universities and commensurate with training and experience.
QUALIFICATIONS: Minimum qualifications include a Ph.D. in plant
genetics, or closely related area. Post-doctoral experience or
prior experience at an Assistant Professor level in molecular
genetic procedures applicable to wheat improvement is desirable.
Demonstrated ability to design and conduct publishable independent
research in molecular mapping and marker-assisted selection is
essential. In addition, successful entry at the Associate Professor
rank requires evidence of an established externally funded research
program and noteworthy publication record. Cooperative team
research is essential.
DATE AVAILABLE:
January 1, 1999, or as soon as a successful candidate is identified.
APPLICATION PROCEDURE:
Review of applications will begin November 16, 1998, and will
continue until a suitable candidate is identified. Send a letter
of interest, curriculum vitae, official transcripts, and arrange
for three letters of reference to be sent directly to:
Dr. Robert L. Westerman, Head
Oklahoma State University
Department of Plant and Soil Sciences
369 Agricultural Hall
Stillwater, OK 74078-6028
Voice: (405) 744-6425
Fax: (405) 744-8687
E-mail: rlw@soilwater.agr.okstate.edu
OSU is an Affirmative Action/Equal Employment Opportunity
Employer Committed to Multicultural Diversity.
************************************************
C. S. Prakash
Tuskegee University
Center for Plant Biotechnology Research
Tuskegee, AL 36088, USA
mailto:Prakash@tusk.edu
http://agriculture.tusk.edu/biotech/biotech.html
Phone (334) 727 8023; Fax (334) 727 8067
************************************************
1 Jul 1998
A postdoc. position is available in my group at University of British
Columbia, Vancouver, Canada. The project is gene therapy for gliomas
using herpes simplex virus vectors. People with background of molecular
virology are specially encouraged to apply. Please send your C.V. to
wjia@unixg.ubc.ca. or fax to 604-875-4663 attention to Dr. William Jia.
8 Jul 1998
We have a vacancy for a PostDoc cell biologist. Please see attached web
page for detals.
Richard V. Giles Ph.D.
School of Biological Sciences
University of Liverpool
Tel +44/151 794 4389
Fax +44/151 794 4349
http://www.liv.ac.uk/~giles/
8 Jul 1998
Post-doctoral fellowship at the Dept of Forest Genetics and Plant
Physiology in Umea, Sweden:
We have an opening for a post-doc in our lab to work on cell cycle
regulation during wood formation in Poplar. We have cloned cDNAs for
several key cell cycle regulators from Poplar and are in the process of
generating transgenic plants with modified levels of these cell cycle
regulators in specific cell types in the wood forming tissues. The
project involves collaboration with a team of scientists investigating
wood formation using a variety of approaches involving analytical
chemistry, microscopy and physiology.
We are interested in employing a highly motivated individual with
background in molecular biology and protein chemistry to work with us on
the project. The work will involve construction and analysis of
transgenic plants, cloning, expression analysis, in-situ hybridisation,
protein phosphorylation. The position is for 1+1 year starting at the
latest by September.
The Dept of Forest Genetics and Plant Physiology employs over 70
scientists and students. We have sophisticated facilities for growth
regulator measurements, confocal microscopy and several green houses.
The city of Umea is a pleasent university town with excellent facilities
for extracuricular activities with swimming pools, tennis and squash
courts. In addition to the forestry department, the University of Umea
has outstanding departments performing research in microbiology, animal
and plant development.
Interested individuals should send a c.v. with name and addresses (fax
and/or email) of three referees to:
Dr. Rishikesh P. Bhalerao or Dr. Goran Sandberg at the address below:
Department of Forest Genetics and Plant Physiology
The Swedish University of Agricultural Sciences
S-901 83
Umea
Sweden
Tel:+46-90-7866282
Fax:+46-90-7865901
Email:rishi.bhalerao@genfys.slu.se or Goran.Sandberg@genfys.slu.se
10 Jul 1998
A postdoctoral position is available to study the regulation of DNA replication
in the context of cell-cycle control. Studies include cloning and
characterization of potential regulators at the G1/S transition in mammalian
system (PNAS 94:526). I am particularly interested in hearing from a person
with experience in chromatin structure, gel shift, nuclear matrices, Western,
immunoprecipitation, and protein kinase assays. Interested individuals are
invited to submit CV and three letters of reference to:
Dr. Hoyun Lee, PhD, Assistant Professor/Career Scientist, Northeastern Ontario
Regional Cancer Centre, 41 Ramsey Lake road, Sudbury, Ontario, Canada P3E 5J1.
FAX: (705) 523-7326. E-mail: hoyunlee@cancercare.on.ca
13 Jul 1998
COMPANY SUMMARY:
The company is mid-sized company specializing in the development and
manufacture of innovative products serving the life science research
market. The company currently offers more than 2,000 products
designed to facilitate gene expression and analysis, gene cloning, PRC
analysis and many other molecular biology techniques used in
developmental genetics, cellular biology, cancer research, antisense
DNA research, genome mapping, neurobiology, oncology and several other
areas. The company is very technology oriented and places great
emphasis on quality, innovation, fiscal stability and responsiveness
and responsibility towards customers and the community.
JOB SUMMARY:
This Product Manager will be responsible for sales revenue and growth
of specific product lines which may include any of the following:
gene expression products, functional analysis products, protein
expression products or general gene reporter products. Due to its
considerable growth rate, the company offers substantial advancement
for suitably qualified applicants.
PRIMARY RESPONSIBILITIES INCLUDE:
· Technology licensing.
· Produce line strategic development.
· Alliance building and maintenance.
· Market research.
· Competitor analysis.
· Sales/distributor training and support
· Management of the transfer of new products from research and
development to operations.
· Development of global launch platforms and product positioning
strategies.
· Satisfying revenue growth targets and specific product lines.
JOB REQUIREMENTS
Education and experience:
· BA(S), MA(S), or Ph.D. in molecular biology, biochemistry, cellular
biology or virology from an accredited institution either domestic
U.S. or foreign with preference given to candidates with molecular
biology background.
· Business training or experience in product management with
preference given to candidates with an MBA in a relevant discipline.
· 3-5 years of technical experience in molecular biology with
preference being given to candidates with directly-related work
experience in companies which product molecular biology kits and
reagents.
· Minimum of two years of directly-relevant product management
experience with preference being given to candidates with product
management experience both domestic and international in scope.
Knowledge and Skills Required:
· Knowledge of modern molecular biology, cell biology and biochemical
techniques and their use in both research and academic environments.
· Good leadership and communication skills along with good analytical
skills are essential.
· Candidates with exceptional detail-orientation are particularly
sought after.
· Must possess excellent communications skills to interface with
scientists both within and without the organization. This includes
excellent proficiency in English (both written and verbal) and in the
use of the scientific literature
· Computer literacy to include operation of a Personal Computer (IBM
clone and/or Mac); proficiency in the use of the Internet.
· Knowledge of and experience in GMP/GLP environments.
· Able to manage multiple priorities and deadlines in an expedient and
decisive manner.
· Must have sufficient emotional maturity and fortitude to flourish in
an environment with constantly changing workloads and work
requirements and must evolve with the position.
If you have an interest in this or other opportunities, please send us
your resume/CV as an Attached File to an email or send by mail/FAX to
RS&A to the attention of Ann Rathbun, Managing Director. All
correspondence is held in strict confidence.
Rathbun, Sapir & Associates
P.O. Box 2337
Sedona, AZ 86339-2337 * USA
(520) 203-0074 Office (520) 203-0075 FAX
E-mail: rathbun@sedona.net
14 Jul 1998
Postdoc Position in Molecular Plant Nematology available September/October 1998
Characterization of genes of secreted proteins of cyst nematodes (Heterodera
spp.). Applicants need to be experienced in molecular biology methodology.
Prior experience with nematodes desirable but not mandatory. The project
will require the use of the following techniques: library screening;
preparation and analysis of DNA, RNA, and protein blots; mRNA in situ
hybridization; production of antibodies; immunolocalization; light microscopy.
Please send a letter, CV, reprints, and names of reference persons to: Dr.
Thomas J. Baum, Iowa State University, Department of Plant Pathology, 351
Bessey Hall, Ames, IA 50011. See
http://www.public.iastate.edu/~trmaier/baumlab/baumfr.html for general
laboratory information. Contact Dr. Baum (e-mail tbaum@iastate.edu or phone
515-294-2398) for additional information.
Thomas J. Baum
Asst. Professor
Iowa State University
Department of Plant Pathology
351 Bessey Hall
Ames, IA 50011 USA
ph. (515) 294-2398 fax (515) 294-9420 e-mail tbaum@iastate.edu
http://www.public.iastate.edu/~trmaier/baumlab/baumfr.html
21 Jul 1998
A postdoctoral position is available to study the regulation of DNA
replication in the context of cell-cycle control. Studies include
cloning and characterization of potential regulators at the G1/S
transition in mammalian system (PNAS 94:526). I am particularly
interested in hearing from a person with experience in chromatin
structure, gel shift, nuclear matrices, Western, immunoprecipitation,
and protein kinase assays. Interested individuals are invited to
submit CV and three letters of reference to: Dr. Hoyun Lee, PhD,
Assistant Professor/Career Scientist, Northeastern Ontario Regional
Cancer Centre, 41 Ramsey Lake road, Sudbury, Ontario, Canada P3E 5J1.
FAX: (705) 523-7326. E-mail: hoyunlee@cancercare.on.ca
23 Jul 1998
DuPont Genomics group is looking for a visiting scientist
(postodoctoral) to work with Maureen Dolan and Antoni Rafalski on a
project involving discovery of single nucleotide polymorphisms (SNPs) in
maize and their use in maize genetics. The candidate should have
practical experience in molecular biology techniques and have a
background in genetics. We would like to make an appointment soon. The
position will be located at the DuPont genomics laboratories in Newark,
DE, near the U. of Delaware campus. Collaboration with Pioneer Hi-Bred
scientists will be involved.
DuPont is an equal opportunity employer.
Please send responses to:
Antoni Rafalski: J-Antoni.RAFALSKI@usa.dupont.com
Maureen Dolan: MAUREEN.DOLAN@usa.dupont.com
27 Jul 1998
A postdoctoral position is available to study the regulation of DNA
replication in the context of cell-cycle control. Studies include
cloning and characterization of potential regulators at the G1/S
transition in mammalian system (PNAS 94:526). I am particularly
interested in hearing from a person with experience in chromatin
structure, gel shift, nuclear matrices, Western, immunoprecipitation,
and protein kinase assays. Interested individuals are invited to
submit CV and three letters of reference to: Dr. Hoyun Lee, PhD,
Assistant Professor/Career Scientist, Northeastern Ontario Regional
Cancer Centre, 41 Ramsey Lake road, Sudbury, Ontario, Canada P3E 5J1.
FAX: (705) 523-7326. E-mail: hoyunlee@cancercare.on.ca
28 Jul 1998
Graduate research assistantship (renewable for up to two years) in
Applied Ecological Genetics available at Clemson University, starting
fall semester 1998 (August) or spring semester 1999 (January). We seek
an individual with an interest in utilizing molecular markers to assess
gene flow (by pollen and seed) from cultivated plants to wild
relatives. The long term goal is to assess ecological risks of
transgene escape from bioengineered crops to wild relatives. Current
research focuses on strawberries, is funded by the Biotechnology Risk
Assessment Program of USDA, and involves a team of scientists at Clemson
including Drs. Abbott and Rajapakse (molecular biology), Spira
(population biology) Tonkyn (theoretical ecology), and Westman
(postdoctoral associate coordinating the research). Candidates should
have background and interest in plant genetics/ecology and experience
using molecular techniques.
Contact Dr. Albert G. Abbott (aalbert@clemson.edu) or Dr. Anne L.
Westman (awestma@clemson.edu), Department of Biological Sciences,
Clemson University, Clemson SC, 29634-1903; Phone 864-656-3060; Fax
864-656-0435. Clemson University is an equal opportunity /affirmative
action employer.
30 Jul 1998
Graduate research assistantship (renewable for up to two years) in
Applied Ecological Genetics available at Clemson University, starting
fall semester 1998 (August) or spring semester 1999 (January). We seek
an individual with an interest in utilizing molecular markers to assess
gene flow (by pollen and seed) from cultivated plants to wild relatives.
The long term goal is to assess ecological risks of transgene escape
from bioengineered crops to wild relatives. Current research focuses on
strawberries, is funded by the Biotechnology Risk Assessment Program of
USDA, and involves a team of scientists at Clemson including Drs. Abbott
and Rajapakse (molecular biology), Spira (population biology) Tonkyn
(theoretical ecology), and Westman (postdoctoral associate coordinating
the research).
Candidates should have background and interest in plant genetics/ecology
and experience using molecular techniques. Contact Dr. Albert G. Abbott
(aalbert@clemson.edu) or Dr. Anne L. Westman (awestma@clemson.edu),
Department of Biological Sciences, Clemson University, Clemson SC,
29634-1903; Phone 864-656-3060; Fax 864-656-0435. Clemson University is
an equal opportunity /affirmative action employer.
4 Aug 1998
Molecular biology Post-doc in Portugal
Algarve University (Faro, Sound of Portugal) offers, starting in October 98
and for 1 year minimum, a position of molecular biologist (post-doc) for
its molecular biology laboratory (Pr Leonor Cancela, e-mail:
lcancela@ualg.pt).
This young team develops in a marine biology context (aquaculture,
biotechnologies and ecology) their research programs on :
Fish ossification, population genetics of fish, marine mollusc cellular
biology and environmental adaptation of algae. To date, 3 professors, 4
post-docs et 5 PhD make up this multidisciplinary team.
PROFILE:
- PhD in Cellular Biology, Physiology or Biochemistry (molecular biology)
- Experience in eucaryotic molecular biology (a broad spectrum of known
techniques would be appreciate) and cell culture
MISSION:
The candidate will work on several current projects about expression and
function of BGP and MGP proteins in fish. These proteins, Bone Gla Protein
and Matrix Gla Protein, are implied in calcification regulation of soft,
bony and cartilaginous tissues.
The work will include the supervision of PhD students and a general
technical support concerning other programs.
SALARY:
270 000 escudos (about 1350 ECU or 1800 US dollars) per month, free of
charges.
Please, sent your application (e-mail preferred) at:
Marc Ohresser
Universidade do Algarve UCTRA
Campus de Gambelas
8000 Faro
Portugal
Tel: (351) 89 800 900 ext. 7217 Fax: (351) 89 818 353 e-mail: mohres@ualg.pt
7 Aug 1998
POST DOCTORAL POSITION AVAILABLE
The Plant Cell Technology Laboratory in the Department of Plant
Agriculture at the University of Guelph invites applications for a post
doctoral position. Candidates must have a Ph.D. in plant sciences with
demonstrated research productivity and experience in classical/ molecular
genetics, or related field. Experience in plant tissue culture and
genetic transformation techniques will be an asset. The successful
candidate will be involved in a variety of research programs currently in
progress in the PCT laboratory. Further details about the various
program can be obtained at: http://www.uoguelph.ca/hortsci/cellculture/.
Salary is competitive and commensurate with experience and
qualifications. Screening of candidates will continue until the position
is filled. Interested candidates should submit a letter of application,
and an complete curriculum vitae, representative reprints and names,
addresses of 3 referees, by 30 August 1998, to: Dr. Praveen K. Saxena,
Department of Plant Agriculture, Plant Biotechnology Division, University
of Guelph, Guelph, Ontario, Canada, N1G 2W1; E-mail: psaxena@
uoguelph.ca; FAX: 519-767-0755.
26 Aug 1998
Two postdoctoral positions are available to study the regulation of DNA
replication in the context of cell-cycle control. Studies include
cloning and characterization of potential regulators at the G1/S
transition in mammalian system (PNAS 94:526). I am particularly
interested in hearing from persons with experience in chromatin
structure, gel shift, nuclear matrices, Western, immunoprecipitation,
and protein kinase assays.
A third postdoctoral position is also available to study repopulation
during radiation therapy. In this study, normal breast cells and advanced
breast cancer cells are used as model systems.
Interested individuals are invited to submit CV and three letters of
reference to: Dr. Hoyun Lee, PhD,
Assistant Professor/Career Scientist, Northeastern Ontario Regional
Cancer Centre, 41 Ramsey Lake road, Sudbury, Ontario, Canada P3E 5J1.
FAX: (705) 523-7326. E-mail: hoyunlee@cancercare.on.ca
29 Aug 1998
Two postdoctoral positions are available to study the regulation of DNA
replication in the context of cell-cycle control. Studies include
cloning and characterization of potential regulators at the G1/S
transition in mammalian system (PNAS 94:526). I am particularly
interested in hearing from persons with experience in chromatin
structure, gel shift, nuclear matrices, Western, immunoprecipitation,
and protein kinase assays.
A third postdoctoral position is also available to study repopulation
during radiation therapy. In this study, normal breast cells and advanced
breast cancer cells are used as model systems.
Interested individuals are invited to submit CV and three letters of
reference to: Dr. Hoyun Lee, PhD,
Assistant Professor/Career Scientist, Northeastern Ontario Regional
Cancer Centre, 41 Ramsey Lake road, Sudbury, Ontario, Canada P3E 5J1.
FAX: (705) 523-7326. E-mail: hoyunlee@cancercare.on.ca
1 Sep 1998
POST-DOCTORAL POSITION IN MEDICAL MYCOLOGY
A Post-Doctoral position is available for studying the role
of mating-type associated genes in virulence of Cryptococcus neoformans,
an important human fungal pathogen. Projects include the isolation and
characterization of genes involved in mating, hyphal development, and/or
virulence. Experience in molecular biology is preferred. The position
is located in the Dept. of Microbiology at the University of Texas
Health Science Center at San Antonio (UTHSCSA) and is funded for up to
three years. The Health Science Center has one of the largest groups of
internationally recognized mycologists working on human fungal pathogens
and offers an excellent opportunity to enter the field of medical
mycology.
The city of San Antonio is one of the ten largest in the
country yet is one of the most affordable to live in. Salary is highly
competitive. Applications may be sent by mail, fax, or e-mail and must
include the following: a detailed C.V., selected reprint(s), and contact
information for three references. Send to:
Brian Wickes, Ph.D.
Dept. of Microbiology, Rm 5.023V
7703 Floyd Curl Dr.
University of Texas Health Science Center at San Antonio
San Antonio, TX 78284-7758
Tel (210) 567-3938
Fax (210) 567-6612
e-mail wickes@uthscsa.edu
1 Sep 1998
Postdoctoral position available ASAP:
To study molecular and cellular biology and pathogenesis of Giardia
lamblia:
Requirements: Experience in molecular biology and preferably
biochemistry and cell biology. Experience with parasites is not needed.
Giardia is a major cause of waterborne intestinal disease and is
also of basic biological interest as one of the earliest known eukaryotic
organisms, with both prokaryotic and eukaryotic properties. Our group's
orientation is unusual because we focus broadly on this organism and are
not tied to specific techniques (Ann. Rev. Microbiol. 50: 679-705,1996).
We ask cutting edge questions and design creative approaches to achieve
incisive answers.
Our well-funded lab has completed the giardial life cycle in vitro
for the first time, by inducing the flagellated "trophozoite" form that
colonizes the small intestine to differentiate into cysts that survive in
cold water. We discovered a novel regulated secretory pathway for the
transport of cyst wall proteins during encystation. Cysts infect a new host
by responding to signals from the host that lead to a rapid and dramatic
differentiation. Excystation entails establishing cellular polarity, cell
division, attachment, increases in metabolism, and antigenic switching.
Giardia is also a valuable model for study of the
prokaryotic-eukaryotic divergence and we are actively involved in
biological aspects of a giardial genome project (PNAS 95:229-234, 1998;
Molecular and Biochemical Parasitology, in press).
Current questions include:
1. How are giardial genes regulated during differentiation?
2. What are the cell signaling pathways in differentiation and
pathogenesis?
3. How are components of the cyst wall transported and how is this
fibrous structure assembled?
4. What are the structure and function of the unusual cysteine-rich
variant surface protein of Giardia?
5. What can Giardial genes and pathways tell us about the evolution of
the eukaryotic cell?
6. How does Giardia make people sick?
For information or to apply, please contact Dr. Frances Gillin:
email: fgillin@ucsd.edu
Current references are needed and laboratory visit is desirable.
Frances D. Gillin, Ph.D.
Professor, Dept. of Pathology
Division of Infectious Diseases
Member, Center for Molecular Genetics
University of California at San Diego
School of Medicine
Telephone:619-543-6146
FAX: 619-543-6614
1 Sep 1998
Hi, all. Our lab is looking for a technician in molecular biology. The
position is available immediately. The current project involves
evolving enzymes in test tube to render them functional under industrial
conditions, by using ramdom mutagenesis and recombination followed by
screning/selection (or the so-called "directed evolution"). We are
looking for someone who is enthusiastic, has careful hands, and can
follow established protocols to the letter. Knowledge in molecular
biology is required, but extensive laboratory experience is not,
although will be a plus. A person with a freshly minted B.S. or M.S.
(and wishing to spend a year to sort his/her life out while working as a
technician) will be gladly considered. Please first contact me at the
email address shown above, attach your CV please.
Thanks.
Zhanglin Lin
-----------------------------------------------------------
Mailing Address:
Division of Chemistry and Chemical Engineering
Caltech 210-41
1200 E. California Blvd.
Pasadena, CA 91125
-----------------------------------------------------------
1 Sep 1998
Postdoctoral Position
in Düsseldorf/Germany
A postdoctoral position (BAT II a) is available in a laboratory working on
Molecular Parasitology and Signal Transduction.
URL: http://www.uni-duesseldorf.de/WWW/MathNat/Parasitology/
The group in Düsseldorf is working on signal transduction molecules in the
human parasitic worm Schistosoma mansoni. These molecules govern the maturation
program of vitelline cells in females, an essential developmental process that
is induced by pairing with the male. After identification of a couple of
female-specifically expressed genes whose activity is regulated by the male,
the new project concerns techniques that have been successfully used in signal
transduction research during the last few years. The program tries to identify
further signalling molecules that react with known molecules by protein-protein
interaction. The methods include the two-hybrid system, cloning of receptor targets
and others. The final goal is to elucidate the signalling pathway that regulates
vitelline cell proliferation and differentiation in female schistosomes and to open
ways to inhibit their action.
The position is open in spring/summer next year, and is first for a one year period
with the possibility for renewal for further four years.
Literature:
Grevelding, C.G., Sommer, G., and Kunz, W. (1997). Female-specific gene
expression in Schistosoma mansoni is regulated by pairing. Parasitology 115,
635-640.
Schüssler, P., Grevelding, C.G., and Kunz, W. (1997). Identification of Ras, MAP
inkases, and a GAP protein in Schistosoma mansoni by immunoblotting and
their putative involvement in male-female interaction. Parasitology 115, 629-
634.
Information:
Prof. Dr. Werner Kunz
Section of Genetic Parasitology
Institute for Genetics, Heinrich-Heine-University, Universitaetsstr. 1, D-40225
Duesseldorf, Germany
Tel.+ Fax: (49)211-81-12333
E-mail: Werner.Kunz@uni-duesseldorf.de